Structure, function and regulation of Pseudomonas aeruginosa porins
نویسندگان
چکیده
منابع مشابه
Identification and characterization of porins in Pseudomonas aeruginosa.
Earlier studies have shown that the major porin species in Pseudomonas aeruginosa outer membrane is protein F (OprF), which produces channels wider than those produced by Escherichia coli porins. In contrast, Yoshihara and Nakae ((1989) J. Biol. Chem. 264, 6297-6301) reported that protein F has no pore-forming activity as measured by the flux of L-arabinose, and that the channels in P. aerugino...
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Single channel current-voltage (IV) relations were measured from proteins that form channels across the outer membranes of Gram-negative bacteria – porins and their mutants in solutions of KCl. The wild-type porins and some of their specific mutants have known x-rays structures, which lays the foundation for this theoretical work. The ionic strength of KCl ranges from 100mM to 3M. Using the alr...
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Porins are proteins that form water-filled channels across the outer membranes of Gram-negative bacteria and thus make this membrane semipermeable. There are four types of porins: general/nonspecific porins, substrate-specific porins, gated porins, and efflux porins (also called channel-tunnels). The recent publication of the genomic sequence of Pseudomonas aeruginosa PAO1 has dramatically incr...
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During the course of chronic cystic fibrosis (CF) infections, Pseudomonas aeruginosa undergoes a conversion to a mucoid phenotype, which is characterized by overproduction of the exopolysaccharide alginate. Chronic P. aeruginosa infections involve surface-attached, highly antibiotic-resistant communities of microorganisms organized in biofilms. Although biofilm formation and the conversion to m...
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ژورنال
عنوان ژورنال: FEMS Microbiology Reviews
سال: 2017
ISSN: 1574-6976
DOI: 10.1093/femsre/fux020